BARD1 anticorps (Internal Region)
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- Antigène Voir toutes BARD1 Anticorps
- BARD1 (BRCA1 Associated RING Domain 1 (BARD1))
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Épitope
- Internal Region
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp BARD1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- BARD1 Antibody detects endogenous levels of total BARD1.
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human BARD1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product BARD1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- BARD1 (BRCA1 Associated RING Domain 1 (BARD1))
- Autre désignation
- BARD1 (BARD1 Produits)
- Synonymes
- anticorps BARD1, anticorps LOC100147913, anticorps ENSMUSG00000060893, anticorps ENSMUSG00000073653, anticorps BRCA1 associated RING domain 1, anticorps BARD1, anticorps bard1, anticorps Bard1
- Sujet
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Description: E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
Gene: BARD1
- Poids moléculaire
- 79 kDa
- ID gène
- 580
- UniProt
- Q99728
- Pathways
- Réparation de l'ADN
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