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BRSK1 anticorps (Internal Region)

BRSK1 Reactivité: Humain, Souris WB, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6256963
  • Antigène Voir toutes BRSK1 Anticorps
    BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))
    Épitope
    • 15
    • 10
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 51
    • 31
    • 20
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 73
    Lapin
    Clonalité
    • 72
    • 1
    Polyclonal
    Conjugué
    • 21
    • 8
    • 8
    • 7
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BRSK1 est non-conjugé
    Application
    • 47
    • 37
    • 14
    • 13
    • 13
    • 10
    • 7
    • 7
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    BRSK1 Antibody detects endogenous levels of total BRSK1.
    Homologie
    Pig,Bovine,Horse,Sheep,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human BRSK1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product BRSK1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))
    Autre désignation
    BRSK1 (BRSK1 Produits)
    Synonymes
    anticorps BRSK1, anticorps hSAD1, anticorps Gm1100, anticorps SAD-B, anticorps SADB, anticorps RGD1563268, anticorps Sad-b, anticorps BR serine/threonine kinase 1, anticorps BRSK1, anticorps Brsk1
    Sujet

    Description: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.

    Gene: BRSK1

    Poids moléculaire
    87 kDa
    ID gène
    84446
    UniProt
    Q8TDC3
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