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RRP8 anticorps (Internal Region)

RRP8 Reactivité: Humain WB, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6257014
  • Antigène Voir toutes RRP8 Anticorps
    RRP8 (Ribosomal RNA Processing 8 (RRP8))
    Épitope
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 22
    • 11
    • 10
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 20
    • 2
    Lapin
    Clonalité
    • 22
    Polyclonal
    Conjugué
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RRP8 est non-conjugé
    Application
    • 13
    • 4
    • 4
    • 2
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    HUCE1 Antibody detects endogenous levels of total HUCE1.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human HUCE1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product RRP8 Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    RRP8 (Ribosomal RNA Processing 8 (RRP8))
    Autre désignation
    RRP8 (RRP8 Produits)
    Synonymes
    anticorps KIAA0409, anticorps 1500003O22Rik, anticorps 2900001K19Rik, anticorps AW538116, anticorps RGD1308302, anticorps ribosomal RNA processing 8, anticorps ribosomal RNA processing 8, methyltransferase, homolog (yeast), anticorps RRP8, anticorps Rrp8
    Sujet

    Description: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

    Gene: RRP8

    Poids moléculaire
    51 kDa
    ID gène
    23378
    UniProt
    O43159
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