CCBP2 anticorps (C-Term)

N° du produit ABIN6257026

Détail du produit anti-CCBP2 anticorps

Antigène: CCBP2 (Chemokine Binding Protein 2 (CCBP2))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCBP2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: CCBP2 Antibody detects endogenous levels of total CCBP2.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CCBP2, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CCBP2

Antigène: CCBP2 (Chemokine Binding Protein 2 (CCBP2))

Autre désignation: ACKR2 (CCBP2 Produits)

Synonymes: anticorps CCBP2, anticorps CCR10, anticorps CCR9, anticorps CMKBR9, anticorps D6, anticorps hD6, anticorps Ccbp2, anticorps LOC733624, anticorps A130091K22Rik, anticorps Cmkbr10, anticorps GPR-9-6, anticorps AI464239, anticorps Cmkbr9, anticorps atypical chemokine receptor 2, anticorps atypical chemokine receptor 2-like, anticorps chemokine receptor D6, anticorps chemokine (C-C motif) receptor 9, anticorps C-C motif chemokine receptor 9, anticorps ACKR2, anticorps Ackr2, anticorps LOC100219492, anticorps LOC733624, anticorps Ccr9, anticorps CCR9

Sujet:

Description: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.

Gene: ACKR2

Poids moléculaire: 34 kDa

ID gène: 1238

UniProt: O00590