CDK5RAP3 anticorps

N° du produit ABIN6257054

Détail du produit anti-CDK5RAP3 anticorps

Antigène: CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDK5RAP3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: CDK5RAP3 Antibody detects endogenous levels of total CDK5RAP3

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide

Isotype: IgG

Information d'application

Indications d'application: WB 1:500~1:1000, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur CDK5RAP3

Antigène: CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3))

Autre désignation: CDK5RAP3 (CDK5RAP3 Produits)

Synonymes: anticorps cdkrap3, anticorps fb33h04, anticorps fc09c05, anticorps id:ibd2920, anticorps wu:fb33h04, anticorps wu:fc09c05, anticorps zgc:86863, anticorps CDK5RAP3, anticorps cdk5rap3, anticorps MGC82350, anticorps C53, anticorps HSF-27, anticorps IC53, anticorps LZAP, anticorps MST016, anticorps OK/SW-cl.114, anticorps PP1553, anticorps 1810007E24Rik, anticorps BC002318, anticorps C81486, anticorps CDK5 regulatory subunit associated protein 3, anticorps CDK5 regulatory subunit associated protein 3 L homeolog, anticorps cdk5rap3, anticorps CDK5RAP3, anticorps cdk5rap3.L, anticorps Cdk5rap3

Sujet:

Description: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).

Gene: CDK5RAP3

Poids moléculaire: 60 kDa

ID gène: 80279

UniProt: Q96JB5