CPEB1 anticorps (Internal Region)

N° du produit ABIN6257072

Détail du produit anti-CPEB1 anticorps

Antigène: CPEB1 (Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CPEB1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: CPEB1 Antibody detects endogenous levels of total CPEB1.

Homologie: Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CPEB1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur CPEB1

Antigène: CPEB1 (Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1))

Autre désignation: CPEB1 (CPEB1 Produits)

Synonymes: anticorps CEBP, anticorps CPE-BP1, anticorps CPEB, anticorps AU024112, anticorps Cpeb, anticorps mCPEB, anticorps CPEB1, anticorps cpeb1, anticorps ZOR-1, anticorps cepb1b, anticorps fd15c06, anticorps wu:fd15c06, anticorps zorba, anticorps cytoplasmic polyadenylation element binding protein 1, anticorps hypothetical protein, anticorps cytoplasmic polyadenylation element binding protein 1 L homeolog, anticorps cytoplasmic polyadenylation element binding protein 1b, anticorps cytoplasmic polyadenylation element binding protein 1 S homeolog, anticorps CPEB1, anticorps Cpeb1, anticorps cpeb1, anticorps LOAG_17395, anticorps cpeb1.L, anticorps cpeb1b, anticorps cpeb1.S

Sujet:

Description: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA, a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites, those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195).

Gene: CPEB1

Poids moléculaire: 63 kDa

ID gène: 64506

UniProt: Q9BZB8

Pathways: Synaptic Membrane