CSNK2A2 anticorps (N-Term)

N° du produit ABIN6257088

Détail du produit anti-CSNK2A2 anticorps

Antigène: CSNK2A2 (Casein Kinase 2, alpha Prime Polypeptide (CSNK2A2))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CSNK2A2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: CSNK2A2 Antibody detects endogenous levels of total CSNK2A2.

Homologie: Pig,Bovine,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CSNK2A2, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur CSNK2A2

Antigène: CSNK2A2 (Casein Kinase 2, alpha Prime Polypeptide (CSNK2A2))

Autre désignation: CSNK2A2 (CSNK2A2 Produits)

Synonymes: anticorps CK2A2, anticorps CSNK2A1, anticorps 1110035J23Rik, anticorps C77789, anticorps CK2, anticorps CSNK2A2, anticorps ck2a2, anticorps csnk2a1, anticorps wu:fi09h12, anticorps casein kinase 2 alpha 2, anticorps casein kinase 2, alpha prime polypeptide, anticorps casein kinase 2 alpha 2 L homeolog, anticorps casein kinase 2, alpha prime polypeptide a, anticorps CSNK2A2, anticorps Csnk2a2, anticorps csnk2a2.L, anticorps csnk2a2, anticorps csnk2a2a

Sujet:

Description: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.

Gene: CSNK2A2

Poids moléculaire: 41 kDa

ID gène: 1459

UniProt: P19784

Pathways: SARS-CoV-2 Protein Interactome