Cyclin T2 anticorps (Internal Region)
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- Antigène Voir toutes Cyclin T2 (CCNT2) Anticorps
- Cyclin T2 (CCNT2)
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Épitope
- Internal Region
- Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Cyclin T2 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
- Specificité
- CCNT2 Antibody detects endogenous levels of total CCNT2.
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human CCNT2, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product CCNT2 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- Cyclin T2 (CCNT2)
- Autre désignation
- CCNT2 (CCNT2 Produits)
- Synonymes
- anticorps fb16c03, anticorps wu:fb16c03, anticorps wu:fj68b10, anticorps zgc:55690, anticorps ccnt2, anticorps cycT, anticorps wu:fi17h07, anticorps zgc:55357, anticorps MGC81210, anticorps CCNT2, anticorps CYCT2, anticorps 2900041I18Rik, anticorps C81304, anticorps CycT2, anticorps CycT2b, anticorps cyclin T2, anticorps cyclin T2b, anticorps cyclin T2a, anticorps cyclin T2 S homeolog, anticorps CCNT2, anticorps ccnt2b, anticorps ccnt2a, anticorps ccnt2.S, anticorps ccnt2, anticorps Ccnt2
- Sujet
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Description: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation, P-TEFB complex interacts with MYOD1, this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes, this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity).
Gene: CCNT2
- Poids moléculaire
- 81kDa
- ID gène
- 905
- UniProt
- O60583
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