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Cyclin T2 anticorps (Internal Region)

CCNT2 Reactivité: Humain, Souris, Rat WB, ELISA, ICC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6257122
  • Antigène Voir toutes Cyclin T2 (CCNT2) Anticorps
    Cyclin T2 (CCNT2)
    Épitope
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 25
    • 2
    Lapin
    Clonalité
    • 25
    • 2
    Polyclonal
    Conjugué
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Cyclin T2 est non-conjugé
    Application
    • 21
    • 13
    • 13
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificité
    CCNT2 Antibody detects endogenous levels of total CCNT2.
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human CCNT2, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product CCNT2 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Date de péremption
    12 months
  • Antigène
    Cyclin T2 (CCNT2)
    Autre désignation
    CCNT2 (CCNT2 Produits)
    Synonymes
    anticorps fb16c03, anticorps wu:fb16c03, anticorps wu:fj68b10, anticorps zgc:55690, anticorps ccnt2, anticorps cycT, anticorps wu:fi17h07, anticorps zgc:55357, anticorps MGC81210, anticorps CCNT2, anticorps CYCT2, anticorps 2900041I18Rik, anticorps C81304, anticorps CycT2, anticorps CycT2b, anticorps cyclin T2, anticorps cyclin T2b, anticorps cyclin T2a, anticorps cyclin T2 S homeolog, anticorps CCNT2, anticorps ccnt2b, anticorps ccnt2a, anticorps ccnt2.S, anticorps ccnt2, anticorps Ccnt2
    Sujet

    Description: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation, P-TEFB complex interacts with MYOD1, this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes, this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity).

    Gene: CCNT2

    Poids moléculaire
    81kDa
    ID gène
    905
    UniProt
    O60583
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