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GPR18 anticorps (Internal Region)

GPR18 Reactivité: Humain, Souris WB, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6257225
  • Antigène Voir toutes GPR18 Anticorps
    GPR18 (G Protein-Coupled Receptor 18 (GPR18))
    Épitope
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 32
    • 11
    • 10
    • 5
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 33
    Lapin
    Clonalité
    • 33
    Polyclonal
    Conjugué
    • 26
    • 3
    • 2
    • 2
    Cet anticorp GPR18 est non-conjugé
    Application
    • 17
    • 15
    • 11
    • 11
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    GPR18 Antibody detects endogenous levels of total GPR18.
    Homologie
    Horse,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human GPR18, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product GPR18 Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    GPR18 (G Protein-Coupled Receptor 18 (GPR18))
    Autre désignation
    GPR18 (GPR18 Produits)
    Synonymes
    anticorps GPR18, anticorps G protein-coupled receptor 18, anticorps GPR18, anticorps Gpr18
    Sujet

    Description: Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937). However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24762058). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083). May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937).

    Gene: GPR18

    Poids moléculaire
    35 kDa
    ID gène
    2841
    UniProt
    Q14330
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