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MYLIP anticorps (Internal Region)

MYLIP Reactivité: Humain, Souris, Rat WB, IHC, ELISA, ICC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6257336
  • Antigène Voir toutes MYLIP Anticorps
    MYLIP (Myosin Regulatory Light Chain Interacting Protein (MYLIP))
    Épitope
    • 15
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 40
    • 36
    • 21
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 40
    • 2
    Lapin
    Clonalité
    • 40
    • 2
    Polyclonal
    Conjugué
    • 17
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MYLIP est non-conjugé
    Application
    • 33
    • 15
    • 13
    • 12
    • 7
    • 6
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificité
    MYLIP Antibody detects endogenous levels of total MYLIP.
    Homologie
    Pig,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human MYLIP, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product MYLIP Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    MYLIP (Myosin Regulatory Light Chain Interacting Protein (MYLIP))
    Autre désignation
    MYLIP (MYLIP Produits)
    Synonymes
    anticorps IDOL, anticorps MIR, anticorps 9430057C20Rik, anticorps Mir, anticorps mylip, anticorps wu:fj36b03, anticorps zgc:55987, anticorps MYLIP, anticorps mir, anticorps zgc:153767, anticorps myosin regulatory light chain interacting protein, anticorps myosin regulatory light chain interacting protein a, anticorps myosin regulatory light chain interacting protein L homeolog, anticorps myosin regulatory light chain interacting protein b, anticorps MYLIP, anticorps Mylip, anticorps mylipa, anticorps mylip.L, anticorps mylip, anticorps mylipb
    Sujet

    Description: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

    Gene: MYLIP

    Poids moléculaire
    50 kDa
    ID gène
    29116
    UniProt
    Q8WY64
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