MAPKSP1 anticorps (Internal Region)

N° du produit ABIN6257364

Détail du produit anti-MAPKSP1 anticorps

Antigène: MAPKSP1 (Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 (MAPKSP1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAPKSP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: LAMTOR3 Antibody detects endogenous levels of total LAMTOR3.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human LAMTOR3, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur MAPKSP1

Antigène: MAPKSP1 (Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 (MAPKSP1))

Autre désignation: LAMTOR3 (MAPKSP1 Produits)

Synonymes: anticorps MAPKSP1, anticorps MAP2K1IP1, anticorps MAPBP, anticorps MP1, anticorps PRO0633, anticorps Ragulator3, anticorps AW556229, anticorps Map2k1ip1, anticorps Mapbp, anticorps Mapksp1, anticorps Mp1, anticorps mapksp1, anticorps zgc:110207, anticorps late endosomal/lysosomal adaptor, MAPK and MTOR activator 3, anticorps LAMTOR3, anticorps Lamtor3, anticorps lamtor3

Sujet:

Description: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.

Gene: LAMTOR3

ID gène: 8649

UniProt: Q9UHA4

Pathways: Signalisation PI3K-Akt