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TYRO3 anticorps (C-Term)

TYRO3 Reactivité: Humain, Souris, Rat WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6257478
  • Antigène Voir toutes TYRO3 Anticorps
    TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))
    Épitope
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 50
    • 17
    • 12
    • 4
    Humain, Souris, Rat
    Hôte
    • 31
    • 23
    • 1
    Lapin
    Clonalité
    • 31
    • 24
    Polyclonal
    Conjugué
    • 41
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TYRO3 est non-conjugé
    Application
    • 33
    • 21
    • 16
    • 8
    • 8
    • 8
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificité
    TYRO3 Antibody detects endogenous levels of total TYRO3.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human TYRO3, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product TYRO3 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Date de péremption
    12 months
  • Antigène
    TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))
    Autre désignation
    TYRO3 (TYRO3 Produits)
    Synonymes
    anticorps TYRO3, anticorps brt, anticorps byk, anticorps dtk, anticorps rse, anticorps sky, anticorps tif, anticorps Xksy, anticorps MGC145734, anticorps DKFZp469I0432, anticorps LOC100231598, anticorps BYK, anticorps Dtk, anticorps RSE, anticorps Sky, anticorps Tif, anticorps Brt, anticorps REK, anticorps ksy, anticorps xksy, anticorps AI323366, anticorps Etk-2, anticorps Rse, anticorps TYRO3 protein tyrosine kinase, anticorps TYRO3 protein tyrosine kinase L homeolog, anticorps TYRO3 protein tyrosine kinase 3, anticorps TYRO3, anticorps tyro3, anticorps Tyro3, anticorps tyro3.L
    Sujet

    Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

    Gene: TYRO3

    Poids moléculaire
    97 kDa ,
    ID gène
    7301
    UniProt
    Q06418
    Pathways
    Signalisation RTK
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