CHP anticorps (Internal Region)
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- Antigène Voir toutes CHP Anticorps
- CHP (Calcium Binding Protein P22 (CHP))
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Épitope
- Internal Region
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Reactivité
- Humain, Rat, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CHP est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- CHP Antibody detects endogenous levels of total CHP.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human CHP, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product CHP Anticorps primaire
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- Indications d'application
- WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- CHP (Calcium Binding Protein P22 (CHP))
- Autre désignation
- CHP1 (CHP Produits)
- Synonymes
- anticorps CHP, anticorps SLC9A1BP, anticorps Sid470p, anticorps p22, anticorps p24, anticorps 1500003O03Rik, anticorps AA960066, anticorps AI046351, anticorps Cahp, anticorps Chp, anticorps Wrch2, anticorps chp, anticorps si:dkey-41n20.1, anticorps wu:fc69b04, anticorps zgc:63904, anticorps wu:fi19e07, anticorps zgc:55363, anticorps calcineurin like EF-hand protein 1, anticorps calcineurin-like EF hand protein 1, anticorps calcineurin-like EF-hand protein 1, anticorps calcineurin-like EF-hand protein 2, anticorps calcineurin-like EF-hand protein 1 L homeolog, anticorps CHP1, anticorps Chp1, anticorps chp1, anticorps chp2, anticorps chp1.L
- Sujet
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Description: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na+/H+ exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH . Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na+/H+ exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.
Gene: CHP1
- Poids moléculaire
- 22 kDa
- ID gène
- 11261
- UniProt
- Q99653
- Pathways
- Proton Transport, Regulation of Carbohydrate Metabolic Process, VEGF Signaling
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