KSR2 anticorps (Internal Region)
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- Antigène Voir toutes KSR2 Anticorps
- KSR2 (Kinase Suppressor of Ras 2 (KSR2))
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Épitope
- Internal Region
- Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp KSR2 est non-conjugé
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Application
- ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- KSR2 Antibody detects endogenous levels of total KSR2.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human KSR2, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product KSR2 Anticorps primaire
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- Indications d'application
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- KSR2 (Kinase Suppressor of Ras 2 (KSR2))
- Autre désignation
- KSR2 (KSR2 Produits)
- Synonymes
- anticorps kinase suppressor of ras 2, anticorps KSR2, anticorps Ksr2
- Sujet
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Description: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
Gene: KSR2
- Poids moléculaire
- 108 kDa
- ID gène
- 283455
- UniProt
- Q6VAB6
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