BUB1B anticorps (C-Term)

N° du produit ABIN6257686

Détail du produit anti-BUB1B anticorps

Antigène: BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BUB1B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: BUB1B Antibody detects endogenous levels of total BUB1B.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human BUB1B, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur BUB1B

Antigène: BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))

Autre désignation: BUB1B (BUB1B Produits)

Synonymes: anticorps BUB1beta, anticorps BUBR1, anticorps Bub1A, anticorps MAD3L, anticorps MVA1, anticorps SSK1, anticorps hBUBR1, anticorps AU045529, anticorps bub1b, anticorps BUB1, anticorps BUB1-like, anticorps BubR1, anticorps BubRI, anticorps CG14030, anticorps CG14030/Bub1, anticorps Dmel\\CG14030, anticorps bub1, anticorps BUB1 mitotic checkpoint serine/threonine kinase B, anticorps BUB1B, mitotic checkpoint serine/threonine kinase, anticorps BUB1B, mitotic checkpoint serine/threonine kinase L homeolog, anticorps Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, anticorps Bub1 kinase, anticorps BUB1B, anticorps Bub1b, anticorps bub1b.L, anticorps bub1b, anticorps Bub1

Sujet:

Description: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.

Gene: BUB1B

Poids moléculaire: 130 kDa

ID gène: 701

UniProt: O60566