Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

POFUT1 anticorps (C-Term)

POFUT1 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, ICC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6257766
  • Antigène Voir toutes POFUT1 Anticorps
    POFUT1 (Protein O-Fucosyltransferase 1 (POFUT1))
    Épitope
    • 13
    • 8
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 41
    • 10
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 40
    • 2
    Lapin
    Clonalité
    • 39
    • 2
    Polyclonal
    Conjugué
    • 27
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Cet anticorp POFUT1 est non-conjugé
    Application
    • 35
    • 27
    • 22
    • 8
    • 8
    • 7
    • 6
    • 4
    • 4
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificité
    POFUT1 Antibody detects endogenous levels of total POFUT1.
    Homologie
    Pig,Bovine,Horse,Sheep,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human POFUT1, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product POFUT1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    POFUT1 (Protein O-Fucosyltransferase 1 (POFUT1))
    Autre désignation
    POFUT1 (POFUT1 Produits)
    Synonymes
    anticorps fut12, anticorps zgc:110472, anticorps o-fut, anticorps o-fuc-t, anticorps o-fuct-1, anticorps pofut1, anticorps DDD2, anticorps FUT12, anticorps O-FUT, anticorps O-Fuc-T, anticorps O-FucT-1, anticorps OFUCT1, anticorps mKIAA0180, anticorps Fut12, anticorps protein O-fucosyltransferase 1, anticorps POFUT1, anticorps pofut1, anticorps Pofut1
    Sujet

    Description: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).

    Gene: POFUT1

    Poids moléculaire
    44 kDa
    ID gène
    23509
    UniProt
    Q9H488
    Pathways
    Signalisation Notch, SARS-CoV-2 Protein Interactome
Vous êtes ici:
Support technique