NCR3 anticorps (Internal Region)

N° du produit ABIN6257790

Détail du produit anti-NCR3 anticorps

Antigène: NCR3 (Natural Cytotoxicity Triggering Receptor 3 (NCR3))

Épitope: Internal Region

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NCR3 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: NCR3 Antibody detects endogenous levels of total NCR3.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human NCR3, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur NCR3

Antigène: NCR3 (Natural Cytotoxicity Triggering Receptor 3 (NCR3))

Autre désignation: NCR3 (NCR3 Produits)

Synonymes: anticorps MGC133750, anticorps 1C7, anticorps CD337, anticorps LY117, anticorps MALS, anticorps NKp30, anticorps Nkp30, anticorps natural cytotoxicity triggering receptor 3, anticorps NCR3, anticorps Ncr3

Sujet:

Description: Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.

Gene: NCR3

Poids moléculaire: 30 kDa

ID gène: 259197

UniProt: O14931

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process