ERI1 anticorps (C-Term)

N° du produit ABIN6257805

Détail du produit anti-ERI1 anticorps

Antigène: ERI1 (Exoribonuclease 1 (ERI1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERI1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: ERI1 Antibody detects endogenous levels of total ERI1.

Homologie: Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ERI1, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ERI1

Antigène: ERI1 (Exoribonuclease 1 (ERI1))

Autre désignation: ERI1 (ERI1 Produits)

Synonymes: anticorps THEX1, anticorps thex1, anticorps zgc:110635, anticorps hexo, anticorps Eri-1, anticorps 3'HEXO, anticorps HEXO, anticorps 3'hexo, anticorps 3110010F15Rik, anticorps Thex1, anticorps eri-1, anticorps RGD1308378, anticorps exoribonuclease 1, anticorps three prime repair exonuclease 1, anticorps exoribonuclease 1 L homeolog, anticorps 3'-5' exonuclease eri-1, anticorps ERI1, anticorps CpipJ_CPIJ003945, anticorps eri1, anticorps eri1.L, anticorps Eri1, anticorps eri-1

Sujet:

Description: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

Gene: ERI1

Poids moléculaire: 40 kDa

ID gène: 90459

UniProt: Q8IV48