BAF53A anticorps (Internal Region)

N° du produit ABIN6257926

Détail du produit anti-BAF53A anticorps

Antigène: BAF53A (Actin-Like 6A (BAF53A))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAF53A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: ACTL6A Antibody detects endogenous levels of total ACTL6A.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ACTL6A, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur BAF53A

Antigène: BAF53A (Actin-Like 6A (BAF53A))

Autre désignation: ACTL6A (BAF53A Produits)

Synonymes: anticorps ACTL6, anticorps ARPN-BETA, anticorps Arp4, anticorps BAF53A, anticorps INO80K, anticorps 2810432C06Rik, anticorps AI851094, anticorps ARP4, anticorps Actl6, anticorps Baf53a, anticorps C79802, anticorps baf53a, anticorps fb52e06, anticorps fl26e12, anticorps chunp6900, anticorps wu:fb52e06, anticorps wu:fl26e12, anticorps actl6, anticorps MGC75671, anticorps RGD1307747, anticorps ACTL6A, anticorps ATARP4, anticorps F15H18.8, anticorps F15H18_8, anticorps actin-related protein 4, anticorps Actin-like protein 4, anticorps CaO19.5623, anticorps actin, anticorps actl6a, anticorps actl6a.L, anticorps arp4, anticorps arpn-beta, anticorps ino80k, anticorps actin like 6A, anticorps actin-like 6A, anticorps actin-related protein 4, anticorps Arp4p, anticorps actin like 6A S homeolog, anticorps ACTL6A, anticorps Actl6a, anticorps actl6a, anticorps ARP4, anticorps actl6a.S

Sujet:

Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Gene: ACTL6A

Poids moléculaire: 47 kDa

ID gène: 86

UniProt: O96019

Pathways: Chromatin Binding, Photoperiodism