CREB3L2 anticorps (Internal Region)

N° du produit ABIN6257984

Détail du produit anti-CREB3L2 anticorps

Antigène: CREB3L2 (CAMP Responsive Element Binding Protein 3-Like 2 (CREB3L2))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CREB3L2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: CREB3L2 Antibody detects endogenous levels of total CREB3L2.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CREB3L2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CREB3L2

Antigène: CREB3L2 (CAMP Responsive Element Binding Protein 3-Like 2 (CREB3L2))

Autre désignation: CREB3L2 (CREB3L2 Produits)

Synonymes: anticorps CREB3L2, anticorps bbf2h7, anticorps BBF2H7, anticorps C530025K05Rik, anticorps Ra69, anticorps SCIRR69, anticorps zgc:158603, anticorps cAMP responsive element binding protein 3 like 2, anticorps cAMP responsive element binding protein 3-like 2, anticorps cAMP responsive element binding protein 3-like 2 L homeolog, anticorps CREB3L2, anticorps creb3l2, anticorps Creb3l2, anticorps creb3l2.L

Sujet:

Description: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827).

Gene: CREB3L2

Poids moléculaire: 58 kDa

ID gène: 64764

UniProt: Q70SY1

Pathways: Thyroid Hormone Synthesis