CKLF anticorps

N° du produit ABIN6258091

Détail du produit anti-CKLF anticorps

Antigène: CKLF (Chemokine-Like Factor (CKLF))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CKLF est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: CKLF6 Antibody detects endogenous levels of total CKLF6

Réactivité croisée: Humain, Souris

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide

Isotype: IgG

Information d'application

Indications d'application: WB 1:500~1:1000, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur CKLF

Antigène: CKLF (Chemokine-Like Factor (CKLF))

Autre désignation: CKLF6 (CKLF Produits)

Synonymes: anticorps C32, anticorps CKLF1, anticorps CKLF2, anticorps CKLF3, anticorps CKLF4, anticorps UCK-1, anticorps 1700001C14Rik, anticorps 1810018M11Rik, anticorps CKLF5, anticorps Cklf2, anticorps Cklf6, anticorps HSPC224, anticorps Cklf1, anticorps chemokine like factor, anticorps chemokine-like factor, anticorps CKLF, anticorps Cklf, anticorps LOC100727126, anticorps LOC101103916

Sujet:

Description: Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.

Gene: CMTM6

Poids moléculaire: 25 kDa

ID gène: 54918

UniProt: Q9NX76