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Cullin 4B anticorps (N-Term)

CUL4B Reactivité: Humain, Souris WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6258095
  • Antigène Voir toutes Cullin 4B (CUL4B) Anticorps
    Cullin 4B (CUL4B)
    Épitope
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 60
    • 22
    • 20
    • 9
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 55
    • 5
    Lapin
    Clonalité
    • 57
    • 3
    Polyclonal
    Conjugué
    • 32
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp Cullin 4B est non-conjugé
    Application
    • 40
    • 18
    • 9
    • 8
    • 7
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificité
    CUL4B Antibody detects endogenous levels of total CUL4B.
    Homologie
    Pig,Bovine,Sheep,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human CUL4B, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product CUL4B Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Date de péremption
    12 months
  • Antigène
    Cullin 4B (CUL4B)
    Autre désignation
    CUL4B (CUL4B Produits)
    Synonymes
    anticorps MRXHF2, anticorps MRXS15, anticorps MRXSC, anticorps SFM2, anticorps 2700050M05Rik, anticorps AA409770, anticorps CUL-4B, anticorps mKIAA0695, anticorps RGD1564494, anticorps im:7140950, anticorps im:7150765, anticorps MGC115611, anticorps Tb03.1J15.620, anticorps sfm2, anticorps mrxsc, anticorps mrxhf2, anticorps cullin 4B, anticorps cullin 4B S homeolog, anticorps CUL4B, anticorps Cul4b, anticorps cul4b, anticorps cul4b.S, anticorps Tb927.3.1290
    Sujet

    Description: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.

    Gene: CUL4B

    Poids moléculaire
    99 kDa?
    ID gène
    8450
    UniProt
    Q13620
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