PLK3 anticorps (Internal Region)
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- Antigène Voir toutes PLK3 Anticorps
- PLK3 (Polo-Like Kinase 3 (PLK3))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PLK3 est non-conjugé
- Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Specificité
- PLK3 Antibody detects endogenous levels of total PLK3.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human PLK3, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product PLK3 Anticorps primaire
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- Indications d'application
- WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- PLK3 (Polo-Like Kinase 3 (PLK3))
- Autre désignation
- PLK3 (PLK3 Produits)
- Synonymes
- anticorps cnk, anticorps wu:fi35f10, anticorps fnk, anticorps prk, anticorps plx3, anticorps MGC89507, anticorps PLK2/3, anticorps NV15469, anticorps Plx3, anticorps CNK, anticorps FNK, anticorps PRK, anticorps Cnk, anticorps Fnk, anticorps polo-like kinase 3 (Drosophila), anticorps polo like kinase 3, anticorps polo-like kinase 3, anticorps polo-like kinase 3 S homeolog, anticorps polo-like kinase 3 L homeolog, anticorps Serine/threonine-protein kinase plk-3, anticorps plk3, anticorps PLK3, anticorps LOC100118436, anticorps plk3.S, anticorps plk3.L, anticorps Plk3, anticorps plk-3
- Sujet
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Description: Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.
Gene: PLK3
- Poids moléculaire
- 70 kDa
- ID gène
- 1263
- UniProt
- Q9H4B4
- Pathways
- Regulation of long-term Neuronal Synaptic Plasticity
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