EHMT1 anticorps (Internal Region)

N° du produit ABIN6258149

Détail du produit anti-EHMT1 anticorps

Antigène: EHMT1 (Euchromatic Histone-Lysine N-Methyltransferase 1 (EHMT1))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EHMT1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: EHMT1 Antibody detects endogenous levels of total EHMT1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human EHMT1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur EHMT1

Antigène: EHMT1 (Euchromatic Histone-Lysine N-Methyltransferase 1 (EHMT1))

Autre désignation: EHMT1 (EHMT1 Produits)

Synonymes: anticorps EUHMTASE1, anticorps Eu-HMTase1, anticorps FP13812, anticorps GLP, anticorps GLP1, anticorps KMT1D, anticorps bA188C12.1, anticorps EHMT1, anticorps G9a, anticorps 9230102N17Rik, anticorps D330003E03, anticorps mKIAA1876, anticorps bZ1O1.6, anticorps si:rp71-1o1.6, anticorps zgc:136244, anticorps euchromatic histone lysine methyltransferase 1, anticorps histone-lysine N-methyltransferase EHMT2, anticorps euchromatic histone-lysine N-methyltransferase 1, anticorps euchromatic histone methyltransferase 1, anticorps euchromatic histone-lysine N-methyltransferase 1a, anticorps EHMT1, anticorps Ehmt1, anticorps LOC100121084, anticorps ehmt1, anticorps ehmt1a

Sujet:

Description: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53.

Gene: EHMT1

Poids moléculaire: 170 kDa

ID gène: 79813

UniProt: Q9H9B1