SMO anticorps (N-Term)

N° du produit ABIN6258327

Détail du produit anti-SMO anticorps

Antigène: SMO (Smoothened Homolog (Drosophila) (SMO))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMO est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: SMO Antibody detects endogenous levels of total SMO.

Homologie: Pig,Bovine,Horse,Rabbit,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SMO, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur SMO

Antigène: SMO (Smoothened Homolog (Drosophila) (SMO))

Autre désignation: SMO (SMO Produits)

Synonymes: anticorps FZD11, anticorps Gx, anticorps SMOH, anticorps Smoh, anticorps E130215L21Rik, anticorps bnb, anticorps smoothened, anticorps XSmo, anticorps smoothened, frizzled class receptor, anticorps smoothened, frizzled class receptor L homeolog, anticorps SMO, anticorps Smo, anticorps smo.L, anticorps smo

Sujet:

Description: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).

Gene: SMO

Poids moléculaire: 86 kDa

ID gène: 6608

UniProt: Q99835

Pathways: Signalisation Hedgehog