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USP28 anticorps (N-Term)

USP28 Reactivité: Humain, Souris, Rat WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6258349
  • Antigène Voir toutes USP28 Anticorps
    USP28 (Ubiquitin Specific Peptidase 28 (USP28))
    Épitope
    • 15
    • 8
    • 7
    • 7
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    N-Term
    Reactivité
    • 40
    • 16
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 52
    • 2
    • 1
    Lapin
    Clonalité
    • 55
    Polyclonal
    Conjugué
    • 17
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp USP28 est non-conjugé
    Application
    • 31
    • 19
    • 13
    • 13
    • 13
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    Specificité
    USP28 Antibody detects endogenous levels of total USP28.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human USP28, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product USP28 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Date de péremption
    12 months
  • Antigène
    USP28 (Ubiquitin Specific Peptidase 28 (USP28))
    Autre désignation
    USP28 (USP28 Produits)
    Synonymes
    anticorps im:7138195, anticorps USP28, anticorps 9830148O20Rik, anticorps AU022237, anticorps mKIAA1515, anticorps ubiquitin specific peptidase 28, anticorps USP28, anticorps usp28, anticorps Usp28
    Sujet

    Description: Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306).

    Gene: USP28

    Poids moléculaire
    122 kDa
    ID gène
    57646
    UniProt
    Q96RU2
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