ATG4C anticorps (N-Term)

N° du produit ABIN6258589

Détail du produit anti-ATG4C anticorps

Antigène: ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG4C est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: ATG4C Antibody detects endogenous levels of total ATG4C.

Homologie: Pig,Horse,Sheep,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ATG4C, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ATG4C

Antigène: ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))

Autre désignation: ATG4C (ATG4C Produits)

Synonymes: anticorps apg4c, anticorps atg4cl, anticorps zgc:86888, anticorps wu:fc56g07, anticorps APG4-C, anticorps APG4C, anticorps AUTL1, anticorps AUTL3, anticorps Apg4-C, anticorps Apg4c, anticorps Atg4cl, anticorps Autl1, anticorps autophagy related 4C cysteine peptidase, anticorps autophagy related 4C, cysteine peptidase, anticorps cysteine protease ATG4C, anticorps ATG4C, anticorps atg4c, anticorps Tsp_15996, anticorps Atg4c

Sujet:

Description: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Gene: ATG4C

Poids moléculaire: 49 kDa

ID gène: 84938

UniProt: Q96DT6

Pathways: Autophagy