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ARID1B anticorps (Internal Region)

ARID1B Reactivité: Humain, Rat, Souris WB, IF, ELISA, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6258593
  • Antigène Voir toutes ARID1B Anticorps
    ARID1B (AT Rich Interactive Domain 1B (SWI1-Like) (ARID1B))
    Épitope
    • 15
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 31
    • 19
    • 13
    • 3
    • 1
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 44
    • 2
    Lapin
    Clonalité
    • 44
    • 2
    Polyclonal
    Conjugué
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ARID1B est non-conjugé
    Application
    • 27
    • 13
    • 13
    • 11
    • 9
    • 9
    • 9
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)
    Specificité
    BAF250B Antibody detects endogenous levels of total BAF250B.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human BAF250B, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product ARID1B Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    ARID1B (AT Rich Interactive Domain 1B (SWI1-Like) (ARID1B))
    Autre désignation
    ARID1B (ARID1B Produits)
    Synonymes
    anticorps fd07d11, anticorps si:dkey-60a16.3, anticorps wu:fd07d11, anticorps 8030481M12, anticorps 9330189K18Rik, anticorps AI836955, anticorps Ardi1b, anticorps B230217J03Rik, anticorps mKIAA1235, anticorps 6A3-5, anticorps Smcf1, anticorps smcf-1, anticorps BAF250B, anticorps BRIGHT, anticorps DAN15, anticorps ELD/OSA1, anticorps MRD12, anticorps OSA2, anticorps P250R, anticorps AT rich interactive domain 1B (SWI1-like), anticorps AT rich interactive domain 1B (SWI-like), anticorps AT-rich interaction domain 1B, anticorps arid1b, anticorps Arid1b, anticorps ARID1B
    Sujet

    Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388).

    Gene: ARID1B

    Poids moléculaire
    170 kDa
    ID gène
    57492
    UniProt
    Q8NFD5
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