NEIL3 anticorps (C-Term)

N° du produit ABIN6258631

Détail du produit anti-NEIL3 anticorps

Antigène: NEIL3 (Nei Endonuclease VIII-Like 3 (NEIL3))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEIL3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: NEIL3 Antibody detects endogenous levels of total NEIL3.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human NEIL3, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur NEIL3

Antigène: NEIL3 (Nei Endonuclease VIII-Like 3 (NEIL3))

Autre désignation: NEIL3 (NEIL3 Produits)

Synonymes: anticorps RGD1310562, anticorps NEIL3, anticorps zgc:103553, anticorps neil3, anticorps MAC12.12, anticorps MAC12_12, anticorps FGP2, anticorps FPG2, anticorps NEI3, anticorps hFPG2, anticorps hNEI3, anticorps AI449477, anticorps BC034753, anticorps C85903, anticorps nei-like DNA glycosylase 3, anticorps nei like DNA glycosylase 3, anticorps GRF zinc finger / Zinc knuckle protein, anticorps nei-like DNA glycosylase 3 L homeolog, anticorps nei like 3 (E. coli), anticorps Neil3, anticorps NEIL3, anticorps neil3, anticorps AT5G13920, anticorps neil3.L

Sujet:

Description: DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA, also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.

Gene: NEIL3

Poids moléculaire: 68 kDa

ID gène: 55247

UniProt: Q8TAT5

Pathways: Réparation de l'ADN