BAZ2A anticorps (N-Term)

N° du produit ABIN6258712

Détail du produit anti-BAZ2A anticorps

Antigène: BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAZ2A est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: BAZ2A Antibody detects endogenous levels of total BAZ2A.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human BAZ2A, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur BAZ2A

Antigène: BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))

Autre désignation: BAZ2A (BAZ2A Produits)

Synonymes: anticorps zgc:101601, anticorps tip5, anticorps bax2a, anticorps walp3, anticorps TIP5, anticorps WALp3, anticorps AA415431, anticorps C030005G16Rik, anticorps C78388, anticorps Tip5, anticorps Walp3, anticorps mKIAA0314, anticorps bromodomain adjacent to zinc finger domain, 2A, anticorps bromodomain adjacent to zinc finger domain 2A, anticorps bromodomain adjacent to zinc finger domain 2A L homeolog, anticorps Baz2a, anticorps baz2a, anticorps BAZ2A, anticorps baz2a.L

Sujet:

Description: Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter, pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).

Gene: BAZ2A

Poids moléculaire: 210 kDa

ID gène: 11176

UniProt: Q9UIF9