FZD1 anticorps (N-Term)

N° du produit ABIN6258786

Détail du produit anti-FZD1 anticorps

Antigène: FZD1 (Fzd1) (Frizzled Family Receptor 1 (Fzd1))

Épitope: N-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZD1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: FZD1 Antibody detects endogenous levels of total FZD1.

Homologie: Pig,Zebrafish,Bovine

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human FZD1, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur FZD1

Antigène: FZD1 (Fzd1) (Frizzled Family Receptor 1 (Fzd1))

Autre désignation: FZD1 (Fzd1 Produits)

Synonymes: anticorps CG17697, anticorps CG3646, anticorps DFZ1, anticorps DFz, anticorps DFz1, anticorps Dfz1, anticorps Dm Fz1, anticorps Dmel\\CG17697, anticorps FZ, anticorps Frz, anticorps Fz, anticorps Fz1, anticorps frz, anticorps fz1, anticorps fz[[1]], anticorps Fz-1, anticorps cFz-1, anticorps Xfrizzled-1, anticorps frizzled1, anticorps frz-1, anticorps frz1, anticorps fzd1-A, anticorps AW227548, anticorps FZ-1, anticorps frizzled, anticorps frizzled class receptor 1, anticorps frizzled class receptor 1 L homeolog, anticorps fz, anticorps FZD1, anticorps Fzd1, anticorps fzd1.L

Sujet:

Description: Receptor for Wnt proteins (PubMed:10557084). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084). Contradictory results showing activation by WNT7B have been described for mouse (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).

Gene: FZD1

Poids moléculaire: 71 kDa

ID gène: 8321

UniProt: Q9UP38

Pathways: Signalisation WNT, Asymmetric Protein Localization