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FZD3 anticorps (Internal Region)

FZD3 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6258790
  • Antigène Voir toutes FZD3 Anticorps
    FZD3 (Frizzled Family Receptor 3 (FZD3))
    Épitope
    • 8
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 47
    • 20
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 40
    • 4
    • 3
    • 3
    Lapin
    Clonalité
    • 44
    • 6
    Polyclonal
    Conjugué
    • 31
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FZD3 est non-conjugé
    Application
    • 40
    • 30
    • 11
    • 11
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    FZD3 Antibody detects endogenous levels of total FZD3.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human FZD3, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product FZD3 Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    FZD3 (Frizzled Family Receptor 3 (FZD3))
    Autre désignation
    FZD3 (FZD3 Produits)
    Synonymes
    anticorps Fz-3, anticorps FZ-3, anticorps fz3, anticorps Xfz3, anticorps frz3, anticorps hfz3, anticorps frz-3, anticorps frizzled3, anticorps frizzled-3, anticorps FZD3, anticorps AU020229, anticorps D930050A07Rik, anticorps Fz3, anticorps fz9, anticorps fzd3, anticorps zg09, anticorps fzd3l, anticorps frizzled class receptor 3, anticorps frizzled class receptor 3 L homeolog, anticorps frizzled class receptor 3a, anticorps frizzled class receptor 3b, anticorps FZD3, anticorps fzd3, anticorps fzd3.L, anticorps Fzd3, anticorps fzd3a, anticorps fzd3b
    Sujet

    Description: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity).

    Gene: FZD3

    Poids moléculaire
    76 kDa
    ID gène
    7976
    UniProt
    Q9NPG1
    Pathways
    Signalisation WNT, Tube Formation
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