FZD8 anticorps (N-Term)
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- Antigène Voir toutes FZD8 Anticorps
- FZD8 (Frizzled Family Receptor 8 (FZD8))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FZD8 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- FZD8 Antibody detects endogenous levels of total FZD8.
- Homologie
- Pig,Bovine,Dog,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human FZD8, corresponding to a region within N-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product FZD8 Anticorps primaire
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- Indications d'application
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- FZD8 (Frizzled Family Receptor 8 (FZD8))
- Autre désignation
- FZD8 (FZD8 Produits)
- Synonymes
- anticorps FZ-8, anticorps hFZ8, anticorps FZD8, anticorps Fz-8, anticorps frizzled8, anticorps xfz8, anticorps Xfz8, anticorps frizzled-8, anticorps hfz8, anticorps Fz8, anticorps fzd8, anticorps fz5, anticorps fz8a, anticorps fzc, anticorps wu:fd02c05, anticorps zg05, anticorps ZG06, anticorps Zfz8b, anticorps fz6, anticorps fz8b, anticorps fzA, anticorps ik:tdsubc_1e1, anticorps xx:tdsubc_1e1, anticorps zfzA, anticorps frizzled class receptor 8, anticorps frizzled class receptor 8 S homeolog, anticorps frizzled class receptor 8 L homeolog, anticorps frizzled class receptor 8a, anticorps frizzled class receptor 8b, anticorps FZD8, anticorps fzd8.S, anticorps fzd8, anticorps Fzd8, anticorps fzd8.L, anticorps fzd8a, anticorps fzd8b
- Sujet
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Description: Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
Gene: FZD8
- Poids moléculaire
- 70 kDa
- ID gène
- 8325
- UniProt
- Q9H461
- Pathways
- Signalisation WNT
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