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GNA12 anticorps (C-Term)

GNA12 Reactivité: Humain, Rat, Souris WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6258823
  • Antigène Voir toutes GNA12 Anticorps
    GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
    Épitope
    • 15
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 44
    • 14
    • 14
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    Humain, Rat, Souris
    Hôte
    • 44
    • 1
    Lapin
    Clonalité
    • 45
    Polyclonal
    Conjugué
    • 16
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GNA12 est non-conjugé
    Application
    • 20
    • 16
    • 13
    • 13
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificité
    GNA12 Antibody detects endogenous levels of total GNA12.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human GNA12, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product GNA12 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Date de péremption
    12 months
  • Antigène
    GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
    Autre désignation
    GNA12 (GNA12 Produits)
    Synonymes
    anticorps NNX3, anticorps RMP, anticorps gep, anticorps gna12, anticorps gna12l, anticorps AI414047, anticorps AI504261, anticorps Galpha12, anticorps G protein subunit alpha 12, anticorps guanine nucleotide binding protein (G protein) alpha 12a, anticorps guanine nucleotide binding protein, alpha 12, anticorps GNA12, anticorps Gna12, anticorps gna12a
    Sujet

    Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).

    Gene: GNA12

    Poids moléculaire
    44 kDa.
    ID gène
    2768
    UniProt
    Q03113
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