HMGB2 anticorps (Internal Region)

N° du produit ABIN6258843

Détail du produit anti-HMGB2 anticorps

Antigène: HMGB2 (High Mobility Group Box 2 (HMGB2))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HMGB2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: HMGB2 Antibody detects endogenous levels of total HMGB2.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human HMGB2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur HMGB2

Antigène: HMGB2 (High Mobility Group Box 2 (HMGB2))

Autre désignation: HMGB2 (HMGB2 Produits)

Synonymes: anticorps HMG2, anticorps C80539, anticorps HMG-2, anticorps Hmg2, anticorps HIGH MOBILITY GROUP BETA 1, anticorps HMG BETA 1, anticorps NFD02, anticorps NFD2, anticorps NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR GROUP D 02, anticorps NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR GROUP D 2, anticorps high mobility group B2, anticorps hmgb2, anticorps hmgb2l, anticorps im:6909096, anticorps wu:fa20b02, anticorps zgc:101854, anticorps wu:fb22b10, anticorps wu:fc95d12, anticorps zgc:123215, anticorps high mobility group box 2, anticorps high mobility group box 2 S homeolog, anticorps high mobility group B2, anticorps high mobility group box 2b, anticorps high mobility group box 2a, anticorps HMGB2, anticorps Hmgb2, anticorps hmgb2.S, anticorps hmgb2b, anticorps hmgb2a

Sujet:

Description: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).

Gene: HMGB2

Poids moléculaire: 27 kDa

ID gène: 3148

UniProt: P26583

Pathways: Cellular Response to Molecule of Bacterial Origin