IREM1 anticorps (Internal Region)

N° du produit ABIN6258909

Détail du produit anti-IREM1 anticorps

Antigène: IREM1 (Immune Receptor Expressed On Myeloid Cells 1 (IREM1))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IREM1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: CLM-1 Antibody detects endogenous levels of total CLM-1.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CLM-1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur IREM1

Antigène: IREM1 (Immune Receptor Expressed On Myeloid Cells 1 (IREM1))

Autre désignation: CD300LF (IREM1 Produits)

Synonymes: anticorps CLIM1, anticorps CLM-1, anticorps CLM1, anticorps Digr2, anticorps F730004D16Rik, anticorps IREM1, anticorps IgSF13, anticorps LMIR3, anticorps Pigr3, anticorps CD300f, anticorps RGD1309733, anticorps IREM-1, anticorps NKIR, anticorps CD300 molecule like family member F, anticorps Cd300 molecule-like family member F, anticorps CD300 molecule like family member f, anticorps Cd300lf, anticorps CD300LF

Sujet:

Description: Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition, recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity).

Gene: CD300LF

Poids moléculaire: 30 kDa

ID gène: 146722

UniProt: Q8TDQ1