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Shugoshin anticorps (N-Term)

SGOL1 Reactivité: Humain, Souris, Rat ELISA, WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6259304
  • Antigène Voir toutes Shugoshin (SGOL1) Anticorps
    Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
    Épitope
    • 10
    • 8
    • 7
    • 6
    • 6
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 44
    • 4
    • 4
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 42
    • 3
    Lapin
    Clonalité
    • 43
    • 2
    Polyclonal
    Conjugué
    • 24
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Shugoshin est non-conjugé
    Application
    • 30
    • 26
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Specificité
    SGOL1 Antibody detects endogenous levels of total SGOL1.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human SGOL1, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product SGOL1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
    Autre désignation
    SGO1 (SGOL1 Produits)
    Synonymes
    anticorps sgo1, anticorps NY-BR-85, anticorps SGO, anticorps Sgo1, anticorps 3300001M08Rik, anticorps C81037, anticorps shugoshin 1, anticorps shugoshin centromeric cohesion 1, anticorps shugoshin 1 L homeolog, anticorps Sgo1, anticorps sgo1, anticorps sgo1.L, anticorps SGO1
    Sujet

    Description: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase.

    Gene: SGO1

    Poids moléculaire
    64 kDa
    ID gène
    151648
    UniProt
    Q5FBB7
    Pathways
    Maintenance of Protein Location
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