STK36 anticorps (Internal Region)

N° du produit ABIN6259306

Détail du produit anti-STK36 anticorps

Antigène: STK36 (serine/threonine Kinase 36 (STK36))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STK36 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: STK36 Antibody detects endogenous levels of total STK36.

Homologie: Pig,Bovine,Horse,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human STK36, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur STK36

Antigène: STK36 (serine/threonine Kinase 36 (STK36))

Autre désignation: STK36 (STK36 Produits)

Synonymes: anticorps FU, anticorps fused-like, anticorps 1700112N14Rik, anticorps B930045J24, anticorps Fused, anticorps mKIAA1278, anticorps fu, anticorps si:dkey-180i4.3, anticorps zgc:152944, anticorps serine/threonine kinase 36, anticorps serine/threonine kinase 36 (fused homolog, Drosophila), anticorps STK36, anticorps Stk36, anticorps stk36

Sujet:

Description: Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia.

Gene: STK36

Poids moléculaire: 170 kDa

ID gène: 27148

UniProt: Q9NRP7