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RRAGA/B anticorps

RRAGA/B Reactivité: Humain, Souris, Rat ELISA, WB, ICC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6259340
  • Antigène Tous les produits RRAGA/B
    RRAGA/B (Ras-Related GTP Binding A/B (RRAGA/B))
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 11
    Lapin
    Clonalité
    • 11
    Polyclonal
    Conjugué
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RRAGA/B est non-conjugé
    Application
    ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificité
    RRAGA/B Antibody detects endogenous levels of total RRAGA/B
     Réactivité croisée
    Humain, Souris, Rat (Rattus)
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide
    Isotype
    IgG
  • Indications d'application
    WB 1:500~1:1000, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C.Stable for 12 months from date of receipt
    Date de péremption
    12 months
  • Antigène
    RRAGA/B (Ras-Related GTP Binding A/B (RRAGA/B))
    Autre désignation
    RRAGA/B (RRAGA/B Produits)
    Sujet

    Description: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.

    Gene: RRAGA

    Poids moléculaire
    34 kDa
    ID gène
    10670
    UniProt
    Q7L523, Q5VZM2
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