CHFR anticorps
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- Antigène Voir toutes CHFR Anticorps
- CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CHFR est non-conjugé
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Application
- ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Specificité
- CHFR Antibody detects endogenous levels of total CHFR
- Réactivité croisée
- Humain, Souris, Rat (Rattus)
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide
- Isotype
- IgG
- Top Product
- Discover our top product CHFR Anticorps primaire
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- Indications d'application
- WB 1:500~1:1000, IF/ICC 1:100-1:500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C.Stable for 12 months from date of receipt
- Date de péremption
- 12 months
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- Antigène
- CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))
- Autre désignation
- CHFR (CHFR Produits)
- Synonymes
- anticorps RNF116, anticorps RNF196, anticorps CHFR, anticorps fc43f10, anticorps si:dkey-69h6.7, anticorps wu:fc43f10, anticorps rnf116, anticorps rnf196, anticorps 5730484M20Rik, anticorps C230082M18, anticorps checkpoint with forkhead and ring finger domains, anticorps checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase, anticorps checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase L homeolog, anticorps CHFR, anticorps chfr, anticorps Chfr, anticorps chfr.L
- Sujet
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Description: E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.
Gene: CHFR
- Poids moléculaire
- 73 kDa
- ID gène
- 55743
- UniProt
- Q96EP1
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