SIX Homeobox 1 anticorps (Internal Region)
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- Antigène Voir toutes SIX Homeobox 1 (SIX1) Anticorps
- SIX Homeobox 1 (SIX1)
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Épitope
- Internal Region
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SIX Homeobox 1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- SIX1 Antibody detects endogenous levels of total SIX1.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human SIX1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product SIX1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- SIX Homeobox 1 (SIX1)
- Autre désignation
- SIX1 (SIX1 Produits)
- Synonymes
- anticorps BOS3, anticorps DFNA23, anticorps TIP39, anticorps BB138287, anticorps six1b, anticorps six2, anticorps zgc:92332, anticorps XSix1, anticorps six1, anticorps zgc:77345, anticorps SIX homeobox 1, anticorps sine oculis-related homeobox 1, anticorps SIX homeobox 1a, anticorps SIX homeobox 1 L homeolog, anticorps SIX homeobox 1b, anticorps SIX1, anticorps Six1, anticorps six1a, anticorps six1.L, anticorps six1b
- Sujet
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Description: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1.
Gene: SIX1
- Poids moléculaire
- 33 kDa
- ID gène
- 6495
- UniProt
- Q15475
- Pathways
- Sensory Perception of Sound, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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