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YOD1 anticorps (Internal Region)

YOD1 Reactivité: Humain WB, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6259576
  • Antigène Voir toutes YOD1 Anticorps
    YOD1 (Ubiquitin Thioesterase OTU1 (YOD1))
    Épitope
    • 9
    • 8
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 34
    • 9
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 34
    Lapin
    Clonalité
    • 34
    Polyclonal
    Conjugué
    • 14
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp YOD1 est non-conjugé
    Application
    • 23
    • 18
    • 14
    • 13
    • 5
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    YOD1 Antibody detects endogenous levels of total YOD1.
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human YOD1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product YOD1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    YOD1 (Ubiquitin Thioesterase OTU1 (YOD1))
    Autre désignation
    YOD1 (YOD1 Produits)
    Synonymes
    anticorps DUBA8, anticorps OTUD2, anticorps PRO0907, anticorps hshin7, anticorps wu:fe01a10, anticorps zgc:112182, anticorps 9930028C20Rik, anticorps Hshin7, anticorps YOD1 deubiquitinase, anticorps YOD1 deubiquitinase L homeolog, anticorps YOD1, anticorps Yod1, anticorps yod1.L, anticorps yod1
    Sujet

    Description: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation (PubMed:27753622).

    Gene: YOD1

    Poids moléculaire
    35 kDa
    ID gène
    55432
    UniProt
    Q5VVQ6
    Pathways
    ER-Nucleus Signaling
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