YOD1 anticorps (Internal Region)

N° du produit ABIN6259576

Détail du produit anti-YOD1 anticorps

Antigène: YOD1 (Ubiquitin Thioesterase OTU1 (YOD1))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp YOD1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: YOD1 Antibody detects endogenous levels of total YOD1.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human YOD1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur YOD1

Antigène: YOD1 (Ubiquitin Thioesterase OTU1 (YOD1))

Autre désignation: YOD1 (YOD1 Produits)

Synonymes: anticorps DUBA8, anticorps OTUD2, anticorps PRO0907, anticorps hshin7, anticorps wu:fe01a10, anticorps zgc:112182, anticorps 9930028C20Rik, anticorps Hshin7, anticorps YOD1 deubiquitinase, anticorps YOD1 deubiquitinase L homeolog, anticorps YOD1, anticorps Yod1, anticorps yod1.L, anticorps yod1

Sujet:

Description: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation (PubMed:27753622).

Gene: YOD1

Poids moléculaire: 35 kDa

ID gène: 55432

UniProt: Q5VVQ6

Pathways: ER-Nucleus Signaling