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KLF anticorps

KLF Reactivité: Humain, Souris, Rat WB, ELISA, ICC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6259607
  • Antigène Tous les produits KLF
    KLF (Kruppel-Like Factor (KLF))
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 3
    Lapin
    Clonalité
    • 3
    Polyclonal
    Conjugué
    • 3
    Cet anticorp KLF est non-conjugé
    Application
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificité
    KLF Antibody detects endogenous levels of total KLF
     Réactivité croisée
    Humain, Souris, Rat (Rattus)
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide
    Isotype
    IgG
  • Indications d'application
    WB 1:500~1:1000, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C.Stable for 12 months from date of receipt
    Date de péremption
    12 months
  • Antigène
    KLF (Kruppel-Like Factor (KLF))
    Autre désignation
    KLF (KLF Produits)
    Sujet

    Description: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.

    Gene: KLF1

    Poids moléculaire
    38 kDa
    ID gène
    10661
    UniProt
    Q13351, Q13887, O75840
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