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Actin-Like 6B anticorps (Internal Region)

ACTL6B Reactivité: Humain, Souris WB, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6259751
  • Antigène Voir toutes Actin-Like 6B (ACTL6B) Anticorps
    Actin-Like 6B (ACTL6B)
    Épitope
    • 8
    • 8
    • 6
    • 2
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 31
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 31
    • 1
    Lapin
    Clonalité
    • 31
    • 1
    Polyclonal
    Conjugué
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Actin-Like 6B est non-conjugé
    Application
    • 25
    • 19
    • 15
    • 13
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    ACTL6B Antibody detects endogenous levels of total ACTL6B.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human ACTL6B, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product ACTL6B Anticorps primaire
  • Indications d'application
    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    Actin-Like 6B (ACTL6B)
    Autre désignation
    ACTL6B (ACTL6B Produits)
    Synonymes
    anticorps MGC110167, anticorps zgc:110167, anticorps ACTL6, anticorps BAF53B, anticorps Actl6, anticorps ArpNa, anticorps Baf53b, anticorps actin-like 6B, anticorps actin like 6B, anticorps actl6b, anticorps ACTL6B, anticorps Actl6b
    Sujet

    Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity).

    Gene: ACTL6B

    Poids moléculaire
    47 kDa
    ID gène
    51412
    UniProt
    O94805
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