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AHCYL1 anticorps (N-Term)

AHCYL1 Reactivité: Humain, Souris, Rat WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6259835
  • Antigène Voir toutes AHCYL1 Anticorps
    AHCYL1 (Adenosylhomocysteinase-Like 1 (AHCYL1))
    Épitope
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 16
    • 10
    • 10
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Rat
    Hôte
    • 14
    • 2
    Lapin
    Clonalité
    • 15
    • 1
    Polyclonal
    Conjugué
    • 16
    Cet anticorp AHCYL1 est non-conjugé
    Application
    • 14
    • 7
    • 5
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    AHCYL1 Antibody detects endogenous levels of total AHCYL1.
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human AHCYL1, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product AHCYL1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    AHCYL1 (Adenosylhomocysteinase-Like 1 (AHCYL1))
    Autre désignation
    AHCYL1 (AHCYL1 Produits)
    Synonymes
    anticorps irbit, anticorps DCAL, anticorps IRBIT, anticorps PRO0233, anticorps XPVKONA, anticorps cb586, anticorps wu:fj66f02, anticorps 1110034F20Rik, anticorps AA409031, anticorps AA414901, anticorps Ahcy-rs3, anticorps Irbit, anticorps adenosylhomocysteinase like 1, anticorps adenosylhomocysteinase like 1 S homeolog, anticorps adenosylhomocysteinase-like 1, anticorps S-adenosylhomocysteine hydrolase-like 1, anticorps AHCYL1, anticorps ahcyl1, anticorps ahcyl1.S, anticorps Ahcyl1
    Sujet

    Description: Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3- and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3- secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity).

    Gene: AHCYL1

    Poids moléculaire
    60 kDa
    ID gène
    10768
    UniProt
    O43865
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