APOBEC3H anticorps (C-Term)

N° du produit ABIN6259988

Détail du produit anti-APOBEC3H anticorps

Antigène: APOBEC3H (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3H (APOBEC3H))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APOBEC3H est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: APOBEC3H Antibody detects endogenous levels of total APOBEC3H.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human APOBEC3H, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur APOBEC3H

Antigène: APOBEC3H (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3H (APOBEC3H))

Autre désignation: APOBEC3H (APOBEC3H Produits)

Synonymes: anticorps A3H, anticorps ARP10, anticorps APOBEC3A, anticorps apolipoprotein B mRNA editing enzyme catalytic subunit 3H, anticorps APOBEC3H

Sujet:

Description: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.

Gene: APOBEC3H

Poids moléculaire: 24 kDa

ID gène: 164668

UniProt: Q6NTF7