ASIP anticorps (Internal Region)

N° du produit ABIN6260077

Détail du produit anti-ASIP anticorps

Antigène: ASIP (Agouti Signaling Protein (ASIP))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASIP est non-conjugé

Application: ELISA, Western Blotting (WB)

Specificité: ASIP Antibody detects endogenous levels of total ASIP.

Homologie: Bovine,Horse,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ASIP, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ASIP

Antigène: ASIP (Agouti Signaling Protein (ASIP))

Autre désignation: ASIP (ASIP Produits)

Synonymes: anticorps AGSW, anticorps AGTI, anticorps AGTIL, anticorps ASP, anticorps SHEP9, anticorps ASIP, anticorps AA960621, anticorps AI256638, anticorps D8Ertd580e, anticorps PAR-3, anticorps Par3, anticorps Pard3a, anticorps agouti signaling protein, anticorps par-3 family cell polarity regulator, anticorps ASIP, anticorps Asip, anticorps asip, anticorps Pard3

Sujet:

Description: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.

Gene: ASIP

Poids moléculaire: 14 kDa

ID gène: 434

UniProt: P42127

Pathways: Cell-Cell Junction Organization, Feeding Behaviour