Ataxin 3 anticorps (Internal Region)
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- Antigène Voir toutes Ataxin 3 (ATXN3) Anticorps
- Ataxin 3 (ATXN3)
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Épitope
- Internal Region
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Ataxin 3 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificité
- Ataxin 3 Antibody detects endogenous levels of total Ataxin 3.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human Ataxin 3, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product ATXN3 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- Ataxin 3 (ATXN3)
- Autre désignation
- ATXN3 (ATXN3 Produits)
- Synonymes
- anticorps Mjd, anticorps zgc:56323, anticorps ATXN3, anticorps at3, anticorps jos, anticorps mjd, anticorps atx3, anticorps mjd1, anticorps sca3, anticorps ataxin-3, anticorps MJD1, anticorps MGC83584, anticorps AT3, anticorps ATX3, anticorps JOS, anticorps MJD, anticorps SCA3, anticorps 2210008M02Rik, anticorps AI463012, anticorps AI647473, anticorps Sca3, anticorps Rsca3, anticorps ataxin 3, anticorps ataxin 3 L homeolog, anticorps ataxin-3, anticorps atxn3, anticorps ATXN3, anticorps atxn3.L, anticorps MICPUN_104046, anticorps MICPUCDRAFT_46658, anticorps Atxn3
- Sujet
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Description: Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460).
Gene: ATXN3
- Poids moléculaire
- 43kDa
- ID gène
- 4287
- UniProt
- P54252
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