SMARCA2 anticorps (C-Term)
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- Antigène Voir toutes SMARCA2 Anticorps
- SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SMARCA2 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Specificité
- Brm Antibody detects endogenous levels of total Brm.
- Homologie
- Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human Brm, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product SMARCA2 Anticorps primaire
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- Indications d'application
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2))
- Autre désignation
- SMARCA2 (SMARCA2 Produits)
- Synonymes
- anticorps BAF190, anticorps BRM, anticorps NCBRS, anticorps SNF2, anticorps SNF2L2, anticorps SNF2LA, anticorps SWI2, anticorps Sth1p, anticorps hBRM, anticorps hSNF2a, anticorps brm, anticorps 2610209L14Rik, anticorps SNF2alpha, anticorps Snf2l2, anticorps brahma, anticorps psa-4, anticorps wu:fa56c07, anticorps wu:fi27f11, anticorps zgc:66238, anticorps Brahma, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 L homeolog, anticorps SMARCA2, anticorps smarca2.L, anticorps Smarca2, anticorps smarca2
- Sujet
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Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Gene: SMARCA2
- Poids moléculaire
- 181 kDa
- ID gène
- 6595
- UniProt
- P51531
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