BTRC anticorps (N-Term)
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- Antigène Voir toutes BTRC Anticorps
- BTRC (beta-Transducin Repeat Containing (BTRC))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp BTRC est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- BTRC Antibody detects endogenous levels of total BTRC.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human BTRC, corresponding to a region within N-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product BTRC Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- BTRC (beta-Transducin Repeat Containing (BTRC))
- Autre désignation
- BTRC (BTRC Produits)
- Synonymes
- anticorps BTRC, anticorps Beta-TrCP, anticorps betaTrCP, anticorps btrcp, anticorps btrcp1, anticorps fbw1a, anticorps fbxw1, anticorps fbxw1a, anticorps fwd1, anticorps btrc, anticorps beta-TrCP, anticorps BETA-TRCP, anticorps FBW1A, anticorps FBXW1, anticorps FBXW1A, anticorps FWD1, anticorps bTrCP, anticorps bTrCP1, anticorps beta-TrCP1, anticorps btrc-a, anticorps Beta-Trcp1, anticorps Fbw1a, anticorps HOS, anticorps Slimb, anticorps b-TrCP, anticorps mKIAA4123, anticorps beta-transducin repeat containing E3 ubiquitin protein ligase, anticorps beta-transducin repeat containing, anticorps beta-TrCP, anticorps beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog, anticorps beta-transducin repeat containing protein, anticorps BTRC, anticorps btrc, anticorps LOC100634006, anticorps Btrc, anticorps btrc.S
- Sujet
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Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:25503564, PubMed:25704143, PubMed:9859996). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PubMed:12077367, PubMed:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PubMed:10835356, PubMed:11238952, PubMed:14681206, PubMed:14603323). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435, PubMed:10497169, PubMed:10644755). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435). SCF(BTRC) mediates the ubiquitination of CEP68, this is required for centriole separation during mitosis (PubMed:25704143, PubMed:25503564). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 (PubMed:16371461).
Gene: BTRC
- Poids moléculaire
- 69kDa
- ID gène
- 8945
- UniProt
- Q9Y297
- Pathways
- Cycle Cellulaire, Signalisation Hedgehog
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